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15-Sep-2019 11:01

On the uncharacteristically cool morning of July 22, 2009, 24 scientists gathered at the National Institutes of Health in Bethesda, Maryland. A paper in the journal was about to implicate the virus as the cause of a devastating disease with a dismissive name: chronic fatigue syndrome, or CFS.

Using a labor-intensive cell culturing technique for hunting retroviruses that he had pioneered in the 1970s, Ruscetti had transmitted the pathogen from patients’ T-cells to uninfected T-cells in the laboratory.Indeed, the controversy over Mikovits’s findings didn’t even have a chance to smolder; it erupted like a wildfire on several continents.The contentious debate reached an apex in the spring of 2010, when one group of government scientists at the FDA found evidence to support Mikovits’s CFS discovery, and another group at the CDC seemed to discredit her findings by failing to reproduce them.Last September Lipkin announced the results of his analysis at a tightly controlled press conference: XMRV was not actually a human pathogen, he said, confirming an earlier report, but a man-made contaminant unwittingly manufactured in a lab in the 1990s.

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After novelistic plot twists that included a police raid, an arrest, and a public tarring and feathering of the outspoken Mikovits, the scientific community is now convinced that XMRV was a false lead.MLVs so dependably cause cancer in lab-bred mice—especially leukemia and lymphoma—that a small fraternity of scientists at the NCI and elsewhere has fruitfully studied these viruses since the 1960s in an effort to understand how human cancer begins.