Sedating antihistamine eczema
Concomitant use of hydroxyzine with alcohol or other CNS depressants should be avoided as this may aggravate these effects (see section 4.5 'Interaction with other medicinal products and other forms of interaction).
The most common adverse effect of the sedating antihistamines is CNS depression.
Due to its sedative properties, use of hydroxyzine should be avoided in severe liver disease due to an increased risk of coma, and in patients with hepatic failure due to possibility of hepatic encephalopathy.
Hydroxyzine elimination is impaired in patients with hepatic dysfunction secondary to primary biliary cirrhosis.
anticholinergic effects) (see sections 4.2 and 4.8).
If sedative effects occur, they may diminish after a few days of treatment.
Other common adverse effects include headache, psychomotor impairment and antimuscarinic effects.
Dosage should be modified for patients with hepatic impairment (see Section 4.2 'Posology and Method of Administration')Atarax should be used with caution in patients with impaired renal function (see Section 4.2 'Posology and Method of Administration').
It is uncertain whether the drug may accumulate or have other adverse effects in such patients.In children and adults, cerebral oedema and upper nephron nephrosis, a deepening coma, tachycardia, QRS widening, heart block, cardiorespiratory collapse/arrest, cardiogenic shock, and death may occur.